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Single or cocktail rabies antibodies both safe in India

Single or cocktail rabies antibodies both safe in India

A recent study evaluated rabies monoclonal antibodies for post-exposure prophylaxis in patients. The comparative observational study was conducted in India from to . The investigation assessed the safety and feasibility of single versus cocktail rabies monoclonal antibodies. Both treatments were found to be safe and well-tolerated among 318 patients with rabies exposure. The study compared a single human anti-rabies monoclonal antibody named Rabishield with a two-monoclonal-antibody cocktail called Twinrab. Consecutive patients with category III animal exposures received either Rabishield or Twinrab in combination with a vaccine recommended by the World Health Organization. The mean age of participants was 29.7 years in the Rabishield group and 32.8 years in the Twinrab group. Local adverse events were uncommon, and no serious systemic adverse events occurred during the evaluation period. However, the single monoclonal antibody required more vials and a higher volume per patient than the cocktail treatment. Rabishield required 2.28 vials per patient compared to 2.00 vials for the cocktail group. The mean infiltration volume was 4.7 millilitres for the single antibody and 4.0 millilitres for the cocktail product. Wastage of the products was similar between the two groups. The authors note that the slightly higher volume and vial requirement for Rabishield may have cost and logistics implications. The results suggest these alternatives could help address shortages of traditional rabies immunoglobulin in resource-limited areas. These findings support broader adoption of monoclonal antibodies to address global immunoglobulin shortages.

Questions about the rabies antibodies study

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Nidhi Fotedar and Haradanahalli Shankariah Ravish carried out the study, titled “Safety and operational feasibility of single versus cocktail rabies monoclonal antibodies for post-exposure prophylaxis in a resource-limited setting”. Read the study.

The study was published in PLOS Neglected Tropical Diseases on . See it in the journal.

A recent study evaluated rabies monoclonal antibodies for post-exposure prophylaxis in patients. The comparative observational study was conducted in India from Oct 2021 to Dec 2022. Read the full study.

Sources

Study: Safety and operational feasibility of single versus cocktail rabies monoclonal antibodies for post-exposure prophylaxis in a resource-limited setting by Nidhi Fotedar and Haradanahalli Shankariah Ravish in PLOS Neglected Tropical Diseases Read the original (opens in a new tab)

Summary written by Animal Writes. Read the original before relying on it.

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